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Process for the preparation of L-biopterin
专利权人:
SHIRATORI PHARMACEUTICAL CO., LTD.;DAIICHI SANKYO COMPANY, LIMITED
发明人:
TAZAWA, SHINNOSUKE
申请号:
DK05822795
公开号:
DK1831223T3
申请日:
2005.12.22
申请国别(地区):
DK
年份:
2013
代理人:
摘要:
To provide a method for producing L-biopterin on a large industrial scale by using a reagent which is inexpensive and easy to handle, without requiring a use of any particular equipment or plants. A method for porducing a biopterin derivative represented by the formula (6): wherein R<;SUP>;1 <;/SUP>;and R<;SUP>;2<;/SUP>;, which are the same or different from each other, each represents a hydrogen atom, an alkyl group, or an aryl group, comprising: reacting a compound belonging to triacetoxy-5-deoxy-L-arabinose phenylhydrazones represented by the formula (4): wherein R<;SUP>;1 <;/SUP>;and R<;SUP>;2 <;/SUP>;are the same as defined above, with 6-hydroxy-2,4,5-triaminopyrimidine (5) under catalytic influence of a Lewis acid in an aqueous solvent.
来源网站:
中国工程科技知识中心
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