BERDINI, VALERIO,OBRIEN, MICHAEL ALISTAIR,CARR, MARIA GRAZIA,EARLY, THERESA RACHEL,GILL, ADRIAN LIAM,TREWARTHA, GARY,WOOLFORD, ALISON JO-ANN,WOODHEAD, ANDREW JAMES,WYATT, PAUL GRAHAM
申请号：
ES10175329
公开号：
ES2539480T3
申请日:
2004.07.22
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A combination comprising: (i) a compound of formula (II): ** ** Formula or salts or tautomers or N-oxides or solvates thereof wherein Y is a bond or an alkylene chain having a length of 1, 2 or 3 carbon atoms R1 is a carbocyclic or heterocyclic group having 3 to 12 ring members wherein the carbocyclic or heterocyclic groups are unsubstituted or are substituted with one or more substituent groups R10 R2 is hydrogen or methyl R3 is selected from carbocyclic groups and non-aromatic heterocyclic having 3 to 12 ring members, wherein the carbocyclic or heterocyclic groups are unsubstituted or are substituted with one or more substituent groups R10 and R10 is selected from halogen, hydroxy, trifluoromethyl, cyano, nitro, carboxy, amino, mono- or di-C1-4 hydrocarbylamino, carbocyclic and heterocyclic groups having from 3 to 12 ring members Ra-Rb group wherein Ra is a bond, O, CO, X1C (X2), C (X2) X1, X1C (X2) X1, S, SO, SO2, NRc, SO2NRc or NRcSO2 and Rb is selected from hydrogen, carbocyclic and heterocyclic groups having from 3 to 12 ring members, and a C1-8 alkyl group optionally substituted with one or more substituents selected from hydroxy, oxo, halogen, cyano, nitro, carboxy, amino, mono- or di-C1-4 hydrocarbylamino, carbocyclic and heterocyclic groups having from 3 to 12 ring members Rc is selected from hydrogen and C1-4 hydrocarbyl and X1 is O, S or NRc and X2 is> = O,> = S or> = NRc and with the proviso that when the substituent group R10 comprises or includes a carbocyclic or heterocyclic group, said carbocyclic or heterocyclic group may be unsubstituted or may itself be substituted with one or more additional substituents R 10 groups and wherein (a) said further substituent groups R10 include carbocyclic or heterocyclic groups which are not themselves further substituted or (b) the said further substituents do not include carbocyclic or heterocyclic groups but are selected but the groups listed above in the definition of R10 and (ii) one or more additional therap
