A surgical stapling and cutting device is constructed with a knife safety lockout element to prevent a knife element from cutting tissue if staples cannot be applied first to the tissue prior to being cut. The surgical stapling and cutting device comprises of a staple holder for holding a staple cartridge, an anvil movably coupled to the staple holder for opposing and deforming staples, a knife safety lockout element for blocking a knife element from being deployed, and a safety spring element for activating or biasing the knife safety lockout element into an active state to block the knife element from being deployed.