System and method for customizing multifocal ophthalmic lenses, such as an intraocular lens (IOL) or the like, that may be tailored for an individual patient or group of patients beyond the selection of a particular IOL power. One or more eye factors of the patient are determined, a set of different multifocal intraocular lenses having a similar base power are determined based on the eye factors, and a multifocal intraocular lens is selected for the patient from the set based on the eye factors.