A tamper-evident pharmaceutical packaging for a pre-filled syringe including a rigid housing made of glass or plastic material, wherein the housing is shaped to receive at least one pre-filled syringe and forms at least one receiving chamber that is shaped to receive and physically protect a single pre-filled syringe wherein the housing has a tip section, a barrel section and a plunger section, respectively dimensioned to receive a tip, a barrel and a plunger of the pre-filled syringe. The housing having has an access opening to the plunger section of each of the at least one receiving chambers, wherein each access opening is arranged to be positioned remote from the tip section of the housing. The packaging also includes at least one openable cover, wherein each cover hermetically seals one of the at least one access openings of the housing.
