MODELE IN VIVO POUR UNE INFECTION PAR UN VER PARASITE ET PROCEDES D'EVALUATION DE COMPOSES ANTIPARASITAIRES, COMPRENANT DES COMPOSES ACTIFS CONTRE LA MALADIE DES VERS DU Cƒ；UR DESCHIENS
BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.;THOMAS JEFFERSON UNIVERSITY
发明人:
ABRAHAM, DAVID,HESS, JESSICA,BONDESEN, BRENDA A.,HARRINGTON, JOHN MATTHEW
申请号：
CA3052054
公开号：
CA3052054A1
申请日:
2018.02.08
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The following discloses a novel model for parasitic worm infection, which is useful for screening for and evaluating the efficacy of antiparasitic agents. In particular, the disclosure provides an immunocompromised mouse model that, for the first time, supports advanced development of Dirofilaria immitis (Di) parasites outside of their definitive hosts. As described herein, early-stage larval forms of Di, the causative agent of Canine Heartworm disease, not only persist in this model, but they develop into mature worms.
