An object of the present invention is to provide a composition for preventing and / or improving an irreversible metabolic disorder associated with cancer. [MEANS FOR SOLVING PROBLEMS] As a result of intensive studies, the present inventors have obtained a composition comprising whey protein hydrolyzate, fat and oil containing lecithin and oleic acid having an action of improving lipid metabolism, and palatinose having an insulin saving effect as essential components. The present inventors have completed the present invention by finding an effect of preventing and / or improving irreversible metabolic disorders associated with cancer. Specifically, in an in vivo test using a tumor cell transplant model, the composition of the present invention does not inhibit the action of an anticancer agent, and muscle mass is a symptom of irreversible metabolic disorders associated with cancer. The effect which prevents and / or improves the reduction decrease etc. of this was discovered. [Selection] Figure 6【課題】本発明の課題は、がんに伴う不可逆性の代謝障害の予防及び／又は改善のための組成物を提供する事である。【解決手段】本発明者らは鋭意検討した結果、ホエイタンパク質加水分解物、脂質代謝改善作用を有するレシチンおよびオレイン酸を含有する油脂、ならびにインスリン節約効果を有するパラチノースを必須成分として含む組成物に、がんに伴う不可逆性の代謝障害の予防及び／又は改善効果を見出し、本発明を完成させた。具体的には、腫瘍細胞移植モデルを用いたin vivo試験において、本発明の組成物が抗がん剤の作用を阻害することなく、がんに伴う不可逆性の代謝障害の症状である筋肉量の減少等を予防及び／又は改善する効果を見出した。【選択図】図６
