COLOMBO, Mario Paolo,MIOTTI, Silvia,TAGLIABUE, Elda,SANGALETTI, Sabina
申请号：
EPEP2016/054177
公开号：
WO2016/135338A1
申请日:
2016.02.26
申请国别(地区):
WO
年份:
2016
代理人:
摘要：
The present invention relates to the interaction between JMJD6 protein and collagen and to the possibility of inhibiting this interaction for the prevention and treatment of fibrosis and of tumor metastases. The invention further relates to a compound that is able to block the interaction between collagen and JMJD6 protein, in particular the invention relates to a new monoclonal antibody that recognizes JMJD6 and is able to block this interaction.La présente invention concerne linteraction entre la protéine JMJD6 et le collagène et la possibilité dinhiber cette interaction pour prévenir et traiter la fibrose et les métastases tumorales. Linvention concerne en outre un composé capable de bloquer linteraction entre le collagène et la protéine JMJD6, en particulier, linvention concerne un nouvel anticorps monoclonal qui reconnaît JMJD6 et est capable de bloquer cette interaction.
