The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Interferon-related developmental regulator 1 (IFRD1), in particular, by targeting natural antisense polynucleotides of Interferon-related developmental regulator 1 (IFRD1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IFRD1.本發明係關於反義寡核苷酸,其特別藉由靶向干擾素相關發育調節子1(IFRD1)之天然反義聚核苷酸來調節干擾素相關發育調節子1(IFRD1)之表現及/或功能。本發明亦關於此等反義寡核苷酸之鑑別及其治療與IFRD1之表現相關之疾病及病症的用途。