There is Ti Gong mono- Seed Jie Kang Group An With Group amine-H3, which to be closed activity or Ju Shou Body Knot, the active Wu Quality of Yi Group amine-H3 Shou Body Steady state activity. It mentions and closes the Which being subjected on object or its Medical Drug for formulaization under a Seed:[wherein respectively Independence on the spot indicates time Jia Ji Ji Missions or nitrogen-atoms (Qian Ti Strip Jian Department of the Visual Qing Condition with 1 or 2 Ge substituent groups wherein except time Jia Ji Ji Mission Qing Condition of X, Y, Z and W Jie Department Visual Qing Condition The substitutions by X, Y, Z and W)A, B and D expressions-C (O)-etc.Q indicates time Jia Ji Ji Mission or nitrogen-atomsR indicates the Visual Qing Condition The Qu Dai Ji Mission of following formula (II-1):(wherein R7 and R8 respectively Independence on the spot Biao Shi More low-carbons Number alkyl Ji Mission etc.)].提供一種具有拮抗組胺與組胺-H3受體之結合之活性、或具有抑制組胺-H3受體穩態活性之活性的物質。提供一種下式(I)化合物或其醫藥上可接受之鹽:[其中X、Y、Z及W各自獨立地表示視情況具有1或2個取代基之次甲基基團,或氮原子(前提條件係其中X、Y、Z及W皆係視情況經取代之次甲基基團之情況除外);A、B及D表示-C(O)-等;Q表示次甲基基團或氮原子;R表示下式(II-1)之視情況經取代基團:(其中R7及R8各自獨立地表示較低碳數烷基基團等)]。
