Robert Arthur Sherry;Frederick Raymond Higton;Tracey Jane Rhoades
发明人:
Robert Arthur Sherry,Tracey Jane Rhoades,Frederick Raymond Higton
申请号：
US10148206
公开号：
US08124124B2
申请日:
2000.11.30
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A compressed tablet composition comprising: a granular component comprising a plurality of solidified melt granules of a non-steroidal anti-inflammatory drug (NSAID) having a melting point in the range 30-300° C. and incorporating a disintegrant uniformly dispersed therein； characterised in that the granules comprise a continuous phase of said non-steroidal anti-inflammatory drug and further characterised in that the tablet composition comprises silicon dioxide present in an amount of 0.05-5.0% by weight of the composition. Preferably, the composition also contains an extra-granular component comprising the silicon dioxide and a lubricant. Further preferably the NSAID is ibuprofen which has a melting point in the range 75-77° C. Optionally the melting process can be carried out in an extruder. Tablets containing advantageous processing properties and dissolution characteristics are obtained.
