Novel indazole derivatives preparation method thereof and pharmaceutical composition for use in preventing or treating cancer containing the same as an active ingredient
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
发明人:
JEON, MOON KOOK,전문국,CHOI, GIL DON,최길돈,LEE KWANGHO,이광호,RHEE, SANG DAL,이상달,GU, SU JIN,구수진,HEO, YUN JEONG,허윤정,JUNG, MYOUNG EUN,정명은,KIM, NAM SOON,김남순,CHO, HYUN SOO,조현수,YOON, JI YONG,윤지용,LEE, JEONG JU,이정주,JEON, MOON KOOKKR,CHOI, GIL DONKR,LEE KWANGHOUS,RHEE, SANG DALKR,GU, SU JINKR,HEO, YUN JEONGKR,JUNG, MYOUNG EUNKR,KIM, NAM SOONKR,CHO, HYUN SOOKR,YOON, JI YONGKR,윤지
申请号：
KR1020160062170
公开号：
KR1017967810000B1
申请日:
2016.05.20
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to a novel indazole derivative, a production method thereof, and a pharmaceutical composition for preventing or treating cancer containing the same as an active ingredient. According to the present invention, the compound, an optical isomer thereof, or a pharmaceutically acceptable salt thereof shows outstanding inhibitory activities on TRAIL-resistance regarding cancer which is resistant to tumor necrosis factor related apoptosis (TRAIL), and thus can be useful for preventing and treating cancer when used as a pharmaceutical composition containing the same as the active ingredient in conjunction with TRAIL.본 발명은 신규한 인다졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 화합물, 이의 광학 이성질체 또는 이의 약학적으로 허용 가능한 염은 TRAIL 내성을 갖는 암에 있어, 우수한 TRAIL 내성 저해 활성을 갖으며, 이를 유효성분으로 함유하는 약학적 조성물로 사용시, 예를 들어 TRAIL과 병용시 암의 예방 및 치료에 유용한 효과가 있다.
