Refers to a compound of formula I, where: u or V is CH2 CH2 ChR2 ChR2, or co W is NR1 or cr3r6 r1 is ar, Het, COA, among others R2 is, AR1, Hal, CN, among others R3 is H, Oh, among others R6 is or AR1 ar is phenyl, Hal, among others AR1 is phenyl, Hal, (CH2), het and Moh, among others S optionally substituted with 1 to 4 Heterocyclic n ATOMS,Or and \/ or s is C1 - C10 alkyl Hal IS F, CL, Br or I M is 0 - 4. Preferred compounds are: 2 - [4 - (4 - methoxy phenyl) piperazin-1-yl] 5,6,7,8-tetrahydro - 3H - quinazolin-4 - One 2 - [4 - (3-fluorophenyl) piperazin-1-yl] - 5,6,7,8-tetrahydro - 3H - quinazolin-4 - One among others. This Compound is an inhibitor of Tankyrase, useful in the treatment of cancer.SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE: U ES CH2 O CHR2 V ES CH2, CHR2 O CO W ES NR1 O CR3R6 R1 ES AR, HET, COA, ENTRE OTROS R2 ES A, AR1, HAL, CN, ENTRE OTROS R3 ES H, OH, ENTRE OTROS R6 ES A O AR1 AR ES FENILO, HAL, A, ENTRE OTROS AR1 ES FENILO, HAL, A, (CH2)MOH, ENTRE OTROS HET ES HETEROCICLICO OPCIONALMENTE SUSTITUIDO CON 1 A 4 ATOMOS DE N, O Y/O S A ES ALQUILO C1-C10 HAL ES F, CL, BR O I M ES 0 - 4. SON COMPUESTOS PREFERIDOS: 2-[4-(4-METOXI-FENIL)-PIPERAZIN-1-IL]5,6,7,8-TETRAHIDRO-3H-QUINAZOLIN-4-ONA 2-[4-(3-FLUOROFENIL)PIPERAZIN-1-IL]-5,6,7,8-TETRAHIDRO-3H-QUINAZOLIN-4-ONA ENTRE OTROS. DICHO COMPUESTO ES UN INHIBIDOR DE LA TANKIRASA, UTIL EN EL TRATAMIENTO DEL CANCER.
