211 ABSTRACT NEW CXCR2 INHIBITORS 5 THE INVENTION RELATES TO COMPOUNDS OF THE FORMULA (1), IN WHICH RI, R2, X, A, B, Z, AND Y1 TO Y4 HAVE THE MEANINGS INDICATED IN THE CLAIMS, AND/OR A PHARMACEUTICALLY ACCEPTABLE SALT AND/OR A PRODRUG THEREOF BECAUSE OF THEIR PROPERTIES AS INHIBITORS OF CHEMOKINE RECEPTORS, ESPECIALLY AS CXCR2 INHIBITORS, THE COMPOUNDS OF THE FORMULA I AND THE PHARMACEUTICALLY ACCEPTABLE SALTS AND PRODRUGS THEREOF ARE SUITABLE FOR THE PREVENTION AND TREATMENT OF 10 CHEMOKINE MEDIATED DISEASES.