A fixation clamp (10), more particularly for use in an external fixation system for holding bone fragments adjacent to each other with the help of fixation elements, comprising at least one clamping assembly (20, 30) having at least one reception (71, 72, 73) to accommodate a fixation element along the longitudinal axis of the reception (71, 72, 73) and at least one locking element (40) extending through the clamping assembly (20, 30) which locking element (40) provides a clamping force to clamp the fixation element upon tensioning the locking element (40). The fixation clamp (10) comprises an actuation element (90) which is in connection with the locking element (40) such that the locking element (40) is actuateable by means of the actuation element (90), and the actuation element (90) is designed such that it is detachable from the locking element (40) after use and that remounting onto the locking element (40) is prevented after having detached the actuation element (90) from the locking element (40).