Microencapsulated and/or enteric coated composition containing a mixture ofprobiotics, prebiotics and ammoniaphilic bacteria with high urease activitywith or without sorbents with specific adsorption afffinities for uremictoxins such as creatinine, uric acid, phenol, indoles, middle molecular weightmolecules and inorganic phosphate and water absorbents are provided. Alsoprovided are methods of allevating symptoms of uremia in a patient whichcomprises administering orally to a patient suffering from uremia amicroencapsulated and/or enteric-coated composition