ELISABETH NAHRWOLD,RALF LUTTERBUESE,INES HERRMANN,MARKUS MUNZ,TOBIAS RAUM,PATRICK HOFFMANN,PETER KUFER,MATTHIAS FRIEDRICH,BENNO RATTEL
申请号：
ARP150102471
公开号：
AR101936A1
申请日:
2015.07.31
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
This provides a Construct of single Chain Antibodies biespec u00edfica that binds to a surface antigen of target cells by means of a First Domain Linking and surface antigen CD3 T cells through a Second binding domain, where Serum Albumin is FUSED to the c-terminus of the Construct of Antibodies.Moreover, polinucle u00f3tido provides a Construct encoding the Antibody, a Vector comprising Said polinucle u00f3tido and a host Cell transformed or transfected with this vector.In addition, this provides a process for the production of the Antibodies of this Construct, a medical use of said Antibodies and a kit comprising Said Antibody construct.Claim 1: construct a single Chain Antibodies biespec u00edfica that binds to a surface antigen of target cells by means of a First Domain Linking and surface antigen CD3 T cells through a Second binding domain.Wherein: the second binding domain binds to an epitope of Human cd3e Chains and Callithrix jacchus, Saguinus oedipus or Saimiri sciureus, where the epitope is part of a sequence of amino acids within the group consisting of SEQ ID nos 7, 8, 9, and 10, and... Thus, at least to the Amino Acid Sequence GLN ASP Gly ASN Glu (SEQ ID no. = 1),Serum Albumin and a FUSED to the c-terminus of the Construct, and the Construct of single Chain Antibodies biespec u00edfica has no Amino Acid Sequence as shown in SEQ ID no. 2 and 3.La presente proporciona un constructo de anticuerpos de cadena sencilla biespecífica que se enlaza a un antígeno de superficie de células objetivo por medio de un primer dominio de enlazamiento y al antígeno de superficie de células T CD3 por medio de un segundo dominio de enlazamiento, donde la albúmina de suero se fusiona al C-terminal del constructo de anticuerpos. Más aún, proporciona un polinucleótido que codifica al constructo de anticuerpos, un vector que comprende dicho polinucleótido y una célula hospedera transformada o transfectada con dicho vector. Además, la presente proporciona un proceso para la prod
