Gerard C. Grosveld,Frank C. Harwood,Ramon I. Klein-Geltink
申请号：
US14111447
公开号：
US20140157443A1
申请日:
2012.04.12
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Provided herein is a novel mTOR-comprising complex, mT-ORC3, which comprises mTOR and the Ets transcription factor TEL2. Specific mTORC3 binding agents and modulating agents are provided, along with kits and methods for the detection of mTORC3. Methods of modulating the activity of mTORC3 or modulating cell growth and/or survival are also provided. Further provided are methods for screening for mTORC3 binding agents and for mTORC3 modulating agents. Various methods of diagnosis and treatment are further provided.
