BAPAT, ABHIJIT S.,MAHESH, GAUTHAMI,GOKHALE, RAJESH S.,SHAH, SAYALI S.,SENGUPTA, SHILADITYA,PRASAD, SUDHANAND,GHOSH, SUMANA,CHAWRAI, SURESH R.,ARORA, NIDHI,REDDY, D. SREEDHAR,MISHRA, MALLIKA,BAJAJ, KIR
申请号：
CA2840215
公开号：
CA2840215A1
申请日:
2012.06.22
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one antifungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA)m-X-(L)n； (ii) [(AFA)m'-X]p-L； (iii) AFA-[X-(L)n']q； or (iv) (AFA)m"-X, wherein: AFA is an antifungal agent or an antibacterial agent； L is a carrier； X is a linker； m ranges from 1 to 10； n ranges from 2 to 10； m' is 1 to 10； p is 1 to 10； n' is 1 to 10； and q is 1 to 10, provided that q' and n are not both 1； and m" is 1 to 10. The invention also provides nonaprticels comprising the conjugate-based prodrugs. Additonoally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.
