Anti-PSGL-1 antibodies and methods of identification and use

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专利权人:

Selexys Pharmaceuticals Corporation

发明人:

Rollins, Scott,Alvarez, Richard

申请号：

AU2009246166

公开号：

AU2009246166B2

申请日:

2009.05.15

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

The present invention is directed to antibodies and binding fragments thereof, which bind with high affinity and specificity to human P-selectin glycoprotein ligand 1 (PSGL-1) and which block both selectin and chemokine binding to PSGL-1 expressed on leukocytes, lymphocytes and endothelial cells and thus which inhibit migration and/or rolling of these cells and to methods for screening for such antibodies and binding fragments thereof and to methods of therapeutic use thereof.

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中国工程科技知识中心

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