THOMAS W. DUBENSKY, JR.;DEREK O'HAGAN;MICHAEL VAJDY;JOHN POLO
发明人:
MICHAEL VAJDY,JOHN POLO,THOMAS W. DUBENSKY, JR.,DEREK O'HAGAN,DEREK OHAGAN
申请号：
US13349326
公开号：
US20120114693A1
申请日:
2012.01.12
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Mucosal delivery of antigens using, for example, a replication-defective gene delivery vehicle, particularly replication-defective alphavirus vectors and particles, is described. Also described are compositions comprising a mucosal adjuvant and one or more antigens derived from HIV. Also provided is the use of these gene delivery vehicles in inducing mucosal, local, and/or systemic immune responses following mucosal immunization regimes.
