COMBINATION OF A NUCLEOSIDE POLYMERASE INHIBITOR WITH A MACROCYCLIC PROTEASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF HEPATITIS C, LIVER FIBROSIS AND IMPAIRED LIVER FUNCTION
BRADFORD, WILLIAMSON, ZIEGLER,SMITH, PATRICK, F,SYMONDS, WILLIAM, T,PORTER, STEVEN, B,YETZER, ELLEN, S,DE LA ROSA, ABEL,ROGERS, MICHAEL, D
申请号：
NZ59452410
公开号：
NZ594524A
申请日:
2010.02.26
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
594524 Disclosed is a composition comprising ?-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine (compound 1) and (1S, 4R, 6S, 14S, 18R)-4-Fluoro-1,3-dihydro-isoindole-2-carboxylic acid 14-tert-butoxycarbonylamino-4-cyclopropanesulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-tricyclo[14.3.0.04,6]nonadec-7-en-18-yl ester (Compound 2). Also disclosed is a method of treating hepatitis C virus infection, liver fibrosis, and impaired liver function in a non-human animal with the composition and the use of the composition in the manufacture of a medicament for the treatment of hepatitis C virus infection, liver fibrosis, and impaired liver function.
