Paula S. Hochman;Christopher D. Benjamin;Jeffrey L. Browning
发明人:
Jeffrey L. Browning,Christopher D. Benjamin,Paula S. Hochman
申请号：
US13037092
公开号：
US08455445B2
申请日:
2011.02.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention relates to compositions and methods comprising “lymphotoxin-β-receptor blocking agents”, which block lymphotoxin-β receptor signalling. Lymphotoxin-β receptor blocking agents are useful for treating lymphocyte-mediated immunological diseases, and more particularly, for inhibiting Th1 cell-mediated immune responses. This invention relates to soluble forms of the lymphotoxin-β receptor extracellular domain that act as lymphotoxin-β receptor blocking agents. This invention also relates to the use of antibodies directed against either the lymphotoxin-β receptor or its ligand, surface lymphotoxin, that act as lymphotoxin-β receptor blocking agents. A novel screening method for selecting soluble receptors, antibodies and other agents that block LT-β receptor signalling is provided.
