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SOLID DISPERSIONS OF INSOLUBLE DRUG AND PREPARATION METHOD THEREOF
专利权人:
LTD.;SK BIOPHARMACEUTICALS CO.
发明人:
Myoung Ki Baek,Augustin Pegan
申请号:
US14441277
公开号:
US20150283243A1
申请日:
2013.11.07
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention relates to a solid dispersion characterized in that it comprises carbamic acid 3-(4-ben-zyloxy-phenyl)-isoxazol-5-ylmethyl ester as an active ingredient and a water-soluble polymer having a glass transition temperature lower than the melting point of the active ingredient as a carrier, and it is prepared via melt extrusion. The solid dispersion of the present invention remarkably increases the solubility and dissolution rate of the active ingredient which is an insoluble drug to efficiently improve the bioavailability when it is orally administered.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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