HOUGHTON, MICHAEL,LAW, JOHN L.,LOGAN, MICHAEL,HOCKMAN, DARREN,LANDI, ABDOLAMIR
申请号：
CA2986342
公开号：
CA2986342A1
申请日:
2016.07.06
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present disclosure provides heterodimeric polypeptides comprising: 1) a variant hepatitis C virus (HCV) E2 polypeptide and an HCV El polypeptide； 2) a variant HCV El polypeptide and an HCV E2 polypeptide； or 3) a variant HCV El polypeptide and a variant HCV E2 polypeptide, where the variant HCV E2 polypeptide and/or the HCV El polypeptide comprises one or more T cell epitopes, present in an HCV polypeptide other than an HCV El polypeptide or an HCV E2 polypeptide. The present disclosure provides nucleic acids encoding a polyprotein that includes El and variant E2, E2 and variant El, or variant E2 and variant El. The present disclosure provides a method of producing an E1/E2 heterodimer of the present disclosure. The present disclosure provides a method of inducing an immune response in an individual. The present disclosure provides variant E2 polypeptides and variant E1 polypeptides； and nucleic acids encoding same.
