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Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
专利权人:
SAMUMED LLC
发明人:
HOOD JOHN,WALLACE DAVID MARK,KC SUNIL KUMAR
申请号:
NZ62932313
公开号:
NZ629323A
申请日:
2013.03.13
申请国别(地区):
NZ
年份:
2016
代理人:
摘要:
Disclsoed herein are indazole compounds of formula I where the substituents are as defined herein. The compounds are intended for use in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer&rsquos disease, lung disease and osteoarthritis). The disclosure particularly relates to the compound: N-(5-(3-(7-(3-fluoropheny1)-3H-imidazo[4,5-c]pyridin-2-y1)-1H-indazol-5-yl)pyridin-3-y1)-3-methylbutanamide. Other examples of the compounds of formula I include: 4-(2-(5-(pyridin-3-yl)-1H-indazol-3-yl)-3H-imidazo[4,5-c]pyridin-7-yl)morpholine and N-(5-(3-(3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)isobutyramide.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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