BENDER, STEVEN LEE,HUANG, HAICHUN,DEVAUX, BRIGITTE,CHEN, HAIBIN,TANAMACHI, DAWN M.,TOY, KRISTOPHER,YANG, LAN,SPROUL, TIM W.,YAMANAKA, MARK,CASPERSON, GERALD FRIES,HU-LOWE, DANA, DAN,JIANG, XIN,LI, GAN
申请号：
MYPI 2010003473
公开号：
MY150246A
申请日:
2009.02.04
申请国别(地区):
MY
年份:
2013
代理人:
摘要：
THE PRESENT DISCLOSURE PROVIDES ISOLATED MONOCLONAL ANTIBODIES, PARTICULARLY HUMAN MONOCLONAL ANTIBODIES, OR ANTIGEN BINDING PORTIONS THEREOF, THAT SPECIFICALLY BIND TO INTEGRIN A5β1 WITH HIGH AFFINITY. NUCLEIC ACID MOLECULES ENCODING THE ANTIBODIES OF THE DISCLOSURE, EXPRESSION VECTORS, HOST CELLS AND METHODS FOR EXPRESSING THE ANTIBODIES OF THE DISCLOSURE ARE ALSO PROVIDED. IMMUNOCONJUGATES, BISPECIFIC MOLECULES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE ANTIBODIES OR ANTIGEN BINDING PORTIONS THEREOF ARE ALSO PROVIDED. THE DISCLOSURE ALSO PROVIDES METHODS FOR TREATING VARIOUS CANCERS USING THE ANTI-A5β1 ANTIBODIES OR ANTIGEN BINDING PORTIONS THEREOF DESCRIBED HEREIN. FIGURE 13C
