The present invention relates to a sustained release pharmaceutical composition comprising mosapride or a salt thereof, wherein the composition of the present invention provides effective blood of the initial mosapride by satisfying a unique two-phase dissolution profile (immediate release phase and delayed release phase). The medium concentration can be reached quickly, the effective blood concentration can be maintained continuously in the later stage, and not only can the dosage of mosapride be increased once a day as a single dosage form, but also the degree of compliance Can also be improved.本発明はモサプリドまたはその塩を含む徐放型医薬組成物に関し、本発明の組成物は独特な２相溶出プロファイル（即時放出相および遅延放出相）を満足させることによって、初期のモサプリドの有効血中濃度に早く到達することができ、後期に有効血中濃度を持続的に維持させ、単一剤形として一日に１回の服用だけでもモサプリドの薬効を高められるだけでなく、服薬順応度も向上させることができる。
