METHODS OF TREATING CANCER WITH A COMBINATION OF GLUCOSE MODULATORS AND BCL-2 INHIBITORS

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专利权人:

EMORY UNIVERSITY

发明人:

Malathy Shanmugam,Richa Bajpai,Lawrence Boise

申请号：

US14919224

公开号：

US20160113925A1

申请日:

2015.10.21

申请国别(地区):

US

年份:

2016

代理人:

摘要：

This disclosure relates to treating or preventing cancers, such as hematological malignancies, by administering a compound that binds BCL2 and one or more compounds that inhibit glucose or glutamine metabolism. In certain embodiments, the compounds that inhibit glucose metabolism are ritonavir optionally in combination with 6-diazo-5-oxo-L-norleucine or any derivative, prodrugs, or salts of these compounds. Contemplated BCL2 binding compounds are ABT-199 (venetoclax), ABT-263 (navitoclax), or ABT-737.

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