KIM, KYEONG SOO,JANG, KI YOUNG,PARK, SEUNG JAE,KIM, YONG IL,PARK, JAE HYUN,WOO, JONG SOO
申请号：
EP12840479
公开号：
EP2744485A4
申请日:
2012.10.15
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
PURPOSE: A soft capsule composite formulation with a tablet is provided to fill high capacity physiologically active ingredients in a small capsule and to improve productivity and drug compliance.CONSTITUTION: A soft capsule composite formulation comprises: a capsule with spherical shapes at both ends and an inner space and a tablet in the inner space. The tablet has an identical shape with the inner space. The tablet has a first part and a second part which have cylindrical bodies with hemispherical end sides and flat end sides. The flat end sides of the first and second parts contact each other. The tablet has a third part with a cylindrical body with flat both ends. The filling rate in the capsule is 0.6 g/mL-1.0 g/mL. The porosity of the capsule is less than 20%. The tablet contains a drug and a pharmaceutically acceptable additive. The additive is selected from the group consisting of a pharmaceutically acceptable diluents, a disintegrant, a binder, a stabilizing agent, and a lubricant.COPYRIGHT KIPO 2013
