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Drug formulations having reduced abuse potential
专利权人:
Supernus Pharmaceuticals; Inc.
发明人:
Rong-Kun Chang,Richard A. Couch,Beth A. Burnside
申请号:
US14563089
公开号:
US09144551B2
申请日:
2014.12.08
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Drug formulations having reduced abuse potential which contain one or more of (1) a bittering agent, (2) a bright deterrent/indicator dye and (3) fine insoluble particulate matter. The bittering agent and dye are in a form which does not affect proper administration of the drug, but the bittering agent creates a bitter side effect when the dosage form is crushed or chemically extracted and nasally, orally, buccally or sublingually administered and the dye produces a bright color when crushed and contacted. The fine insoluble particulate matter hinders extraction of the drug from the dosage form and, when crushed, can deter intravenous injection because of the presence of the insoluble particles or hinder injection by blocking an intravenous needle. The bright color of the dye, when extracted, also has a psychologically deterrent effect on intravenous abusers.
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中国工程科技知识中心
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