Young Nam Lee,Ho Young Hwang,Sang Myoung Noh,Hee-Jeong Cho,Ah-Reum Chae,Ji Hee Lee,Min Hyo Ki,Jong Lae Lim
申请号：
US14357375
公开号：
US09173853B2
申请日:
2012.11.09
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed is a pharmaceutical composition for gene delivery, comprising: (i) a gene (ii) a water-soluble chitosan (iii) a thiamine pyrophosphate or a pharmaceutically acceptable salt thereof (iv) a protamine or a pharmaceutically acceptable salt thereof and (v) a neutral or anionic phospholipid. The composition can introduce a gene into cells safely and effectively. Composed of non-toxic and injectable components, the composition is safe for the body and can be advantageously commercialized. Notably, it can deliver a gene at high efficiency in vivo as well as in vitro, and is stable in the blood.
