Christian Klein;Oliver Ast;Thomas U. Hofer;Pablo Umana;Peter Bruenker;Ekkehard Moessner;Ralf Hosse
发明人:
Oliver Ast,Peter Bruenker,Thomas U. Hofer,Ralf Hosse,Christian Klein,Ekkehard Moessner,Pablo Umana
申请号：
US13457039
公开号：
US09447159B2
申请日:
2012.04.26
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention generally relates to antigen-specific immunoconjugates for selectively delivering effector moieties that influence cellular activity. More specifically, the invention provides novel immunoconjugates comprising a first antigen binding moiety, an Fc domain and a single effector moiety. In addition, the present invention relates to polynucleotides encoding such immunoconjugates, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the immunoconjugates of the invention, and to methods of using these immunoconjugates in the treatment of disease.
