Università degli Studi di Milano - Bicocca;CVIE Therapeutics Limited
发明人:
申请号：
EP18185753.3
公开号：
EP3599243A1
申请日:
2018.07.26
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Disclosed are compounds of formula (I)wherein X, Y, Z are annular atoms comprised in a five-membered carbocyclic or heterocyclic ring, selected from the group consisting of CH, NH, N, O, S； said carbocyclic or heterocyclic ring being optionally substituted with amino (C1-C4) linear or branched alkyl or guanidine or guanidino (C1-C4) linear or branched alkyl；with the proviso that the heterocycle ring is not furyl；n is 0 or 1；R is H or OH；the dotted line represents an optional double bond C=C； the thick line represents a bond in the β configuration； the wavy line represents a bond both in the α and β configuration；their enantiomeric and/or diastereomeric mixtures, their pharmaceutically acceptable salts, their solvates, hydrates； their metabolite and metabolic precursors.The compounds of formula (I) are for use as medicaments, in particular for the treatment of acute or chronic heart failure. Oral administration is also possible.
