ANTI-IL-6 RECEPTOR ANTIBODY

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专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人:

TOMOYUKI IGAWA,MIKA SAKURAI,TETSUO KOJIMA,TATSUHIKO TACHIBANA,HIROTAKE SHIRAIWA,HIROYUKI TSUNODA,ATSUHIKO MAEDA

申请号：

MYPI 2010001313

公开号：

MY162534A

申请日:

2008.09.26

申请国别(地区):

MY

年份:

2017

代理人:

摘要：

THE PRESENT INVENTORS SUCCEEDED IN DISCOVERING SPECIFIC AMINO ACID MUTATIONS IN THE VARIABLE REGION, FRAMEWORK REGION, AND CONSTANT REGION OF TOCILIZUMAB, AND THIS ENABLES TO REDUCE IMMUNOGENICITY RISK AND THE HETEROGENEITY ORIGINATED FROM DISULFIDE BONDS IN THE HINGE REGION, AS WELL AS TO IMPROVE ANTIGEN BINDING ACTIVITY, PHARMACOKINETICS, STABILITY UNDER ACIDIC CONDITIONS, AND STABILITY IN HIGH CONCENTRATION PREPARATIONS.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/