The present invention provides novel compounds having the general formula (I), wherein R2, R3, R4, R5, R6, R7, R8, X, A and R11 are as described herein, A composition comprising said compound and the treatment of HtrA1-mediated eye diseases such as wet or atrophic age-related macular degeneration, geographic atrophy, diabetic retinopathy, retinopathy of prematurity and polypoidal choroidal vasculopathy or Methods for using the compounds as serine protease HtrA1 inhibitors for prevention are provided.本発明は、一般式（Ｉ）［式中、Ｒ２、Ｒ３、Ｒ４、Ｒ５、Ｒ６、Ｒ７、Ｒ８、Ｘ、Ａ及びＲ１１は、本明細書に記載されるとおりである］を有する新規化合物、該化合物を含む組成物、並びにＨｔｒＡ１媒介性眼疾患、例えば、滲出型又は萎縮型の加齢黄斑変性症、地図状萎縮、糖尿病性網膜症、未熟児網膜症及びポリープ状脈絡膜血管症の治療又は予防のための、セリンプロテアーゼＨｔｒＡ１阻害剤としての該化合物の使用方法を提供する。
