The Board of Trustees of the Leland Stanford Junior University
发明人:
SHAMLOO, Mehrdad,JAHANGIR, Alam,YI, Bitna,EVANS, Andrew Kelley,GREEN, Michael John
申请号：
EP17796976
公开号：
EP3454845A4
申请日:
2017.05.12
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Adrenergic receptor modulating compounds and methods of using the same are provided. Also provided are methods of treating a subject for a disease or condition associated with an adrenergic receptor including administering a therapeutically effective amount of the subject compound. Aspects of the disclosure include a method of modulating an inflammatory pathway in a cell, such as the production of TNF-alpha in the cell. The method can include contacting a cell with a β1-selective adrenergic receptor modulating compound to selectively activate a cAMP pathway over a beta-arrestin pathway in the cell. Pharmaceutical compositions and kits which include the subject compounds are provided.
