The present invention relates to compositions and methods for treating lipid disorders in a subject. In one embodiment, the compositions of the present invention can be used to inhibit protease proprotein convertase subtilisin-like kexin type 9 (PCSK9). In another embodiment, the compositions of the present invention can be used to disrupt the protein-protein interaction between PCSK9 and low-density lipoprotein receptor (LDLR).
