COULTER, Tom,DAMMENT, Stephen,PACE, Alessandro,PALMER, Daniel
申请号：
PL17715654
公开号：
PL3347055T3
申请日:
2017.03.29
申请国别(地区):
PL
年份:
2019
代理人:
摘要：
The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0； b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution； and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.
