UNIVERSITY OF MASSACHUSETTS;THE GENERAL HOSPITAL CORPORATION;MASSACHUSETTS EYE AND EAR INFIRMARY
发明人:
Patricia K. DONAHOE,Demetrios VAVVAS,David PEPIN,Mien Van HOANG,Robert H. BROWN,Guangping GAO
申请号：
US16288491
公开号：
US20190351026A1
申请日:
2019.02.28
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to methods to treat a neurodegenerative disease or disorder, e.g., a motor neuron disease in a subject, whereby the subject is administered a recombinant human Mullerian Inhibiting Substance (MIS) protein as disclosed herein, wherein the recombinant human MIS protein comprises a modified Kex cleavage site for increased cleavage. The recombinant human MIS protein can be produced from a pre-proprotein comprising a non-MIS leader sequence or a functional fragment thereof in place of the MIS leader sequence.
