Compositions comprising modulators of N-terminus activation of the androgen receptor, such as EPI-002 and EPI-506, and a second therapeutic agent are provided. Use of such compositions for treatment of various indications, including prostate cancer, are also provided.L'invention concerne des compositions comprenant des modulateurs de l'activation N-terminale du récepteur d'androgène, tels que EPI-002 et EPI-506 et un second agent thérapeutique. L'invention concerne également l'utilisation de telles compositions pour le traitement de diverses indications, en particulier le cancer de la prostate.