ENHANCEMENT OF EXPRESSION OF A SINGLE-STRANDED, HETEROLOGOUS NUCLEOTIDE SEQUENCE FROM RECOMBINANT VIRAL VECTORS BY DESIGNING THE SEQUENCE SUCH THAT IT FORMS INSTRASTRAND BASE PAIRS
Recombinant viral vectors, especially parvovirus such as adeno-associatedvirus (AAV) vectors, capable of enhanced expression of heterologous sequences,and methods for their construction and use, are provided. The vectors have astructure, or are capable of rapidly adopting a structure, which involvesintrastrand base pairing of at least one region in a heterologous sequence.