RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
发明人:
Jerry R. MENDELL,Brian K. KASPAR,Samiah AL-ZAIDY
申请号：
US15517623
公开号：
US20170246322A1
申请日:
2015.10.09
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The disclosure relates to methods for treating subjects with musculoskeletal diseases or with muscle wasting not associated with a musculoskeletal disease by gene transfer with recombinant adeno-associated viruses (rAAV) encoding myostatin inhibitors such as follistatin-344. The rAAV are administered prior to development of diffuse muscle fibrosis in a subject, or the rAAV administration avoids regions of muscle fibrosis in a subject.
