pharmaceutical composition, methods for treating a disease or condition in a human and for inhibiting the activity of a phosphatidylinositol 3-kinase polypeptide and excessive or destructive immune reactions or cancer cell growth or proliferation, kit, compound, pharmaceutically acceptable salt , isomer or mixture thereof, and use of a compound, pharmaceutically acceptable salt or mixture thereof.
BARTON W. PHILLIPS,DEVAN NADUTHAMBI,GARY PHILLIPS,JENNIFER TREIBERG,JERRY EVARTS,JOSHUA KAPLAN,JOSHUA VAN VELDHUIZEN,KIRK L. STEVENS,LEENA PATEL,MUSONG KIM,STEPHANE PERREAULT,SUET CHUNG YEUNG,WILLIAM
申请号：
BR112016028819
公开号：
BR112016028819A2
申请日:
2015.06.10
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present application relates to compounds of formula (j), or pharmaceutically acceptable salts, isomers or a mixture thereof, wherein n, m, q, a ', w1, w2, w3, r1, r2 and r3 are described. in this document. The compounds are inhibitors of phosphatidylinositol 3-kinase (pi3k) activities and are useful for treating conditions mediated by one or more pi3k isoforms. The present application further provides pharmaceutical compositions comprising a compound of formula (j), or pharmaceutically acceptable salts, isomers, tautomers or a mixture thereof, and methods for using such compounds and compositions to treat conditions mediated by one or more isoforms. from pi3k.o presente pedido refere-se a compostos de fórmula (j), ou sais farmaceuticamente aceitáveis, isômeros ou uma mistura dos mesmos, em que n, m, q, a', w1, w2, w3, r1, r2 e r3 são descritos no presente documento. os compostos são inibidores das atividades de fosfatidilinositol 3-quinase (pi3k) e são úteis para tratar condições mediadas por uma ou mais isoformas de pi3k. o presente pedido fornece, ainda, composições farmacêuticas que incluem um composto de fórmula (j), ou sais farmaceuticamente aceitáveis, isômeros, tautômeros ou uma mistura dos mesmos, e métodos para usar esses compostos e composições para tratar condições mediadas por uma ou mais isoformas de pi3k.
