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METHODS FOR TREATING A VARIETY OF DISEASES AND CONDITIONS, AND COMPOUNDS USEFUL THEREFOR
专利权人:
发明人:
申请号:
EP08840146.8
公开号:
EP2205072B1
申请日:
2008.10.14
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
In accordance with the present invention, there are provided novel compounds that have a variety of properties, i.e., antioxidant, anti-inflammatory, antiviral, antibacterial, and antifungal properties. Invention compounds, therefore, have the ability to impart a variety of beneficial physiological effects, e.g., to protect neurons and/or to promote neuroregeneration and/or to promote memory formation and/or to act as protein phosphatase or kinase inhibitors and/or to act as lipoxygenase inhibitors. Such compounds are useful for treatment of a variety of indications, including neurodegenerative diseases and conditions, diabetes, ischemia associated with heart disease, and memory deficit. In another aspect of the present invention, there are also provided formulations containing one or more of the above-described compounds, optionally further containing additional neurologically active compound(s) and/or adjuvants to facilitate delivery thereof across the blood/brain barrier. In still another aspect of the present invention, there are further provided methods for treating a wide variety of neurological indications, e.g., acute neural injuries, chronic injuries, promoting memory formation, and the like.Cette invention concerne de nouveaux composés ayant un certain nombre de propriétés, dont des propriétés antioxydantes, anti-inflammatoires, antivirales, antibactériennes et antifongiques. Les composés de linvention peuvent donc procurer différents avantages physiologiques, par exemple protéger les neurones et/ou promouvoir la neurodégénérescence et/ou promouvoir la formation de la mémoire et/ou agir comme inhibiteurs de protéine-phosphatase ou de protéine-kinase et/ou agir comme inhibiteurs de lipoxygénase. Ces composés sont utilisés dans le traitement de différentes indications, y compris les maladies et affections neurodégénérescentes, le diabète, lischémie associée avec la cardiopathie et le déficit de la mémoire. Dans un autre aspect, linvention concerne aussi des
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