Disclosed are heteroaryl compounds that are useful in regulating theexpression ofinterleukin-6 (IL-6) and/or vascular cell adhesion molecule-1 (VCAM- 1), andtheiruse in the treatment and/or prevention of cardiovascular and inflammatorydiseasesand related disease states, such as, for example, atherosclerosis, asthma,arthritis,cancer, multiple sclerosis, psoriasis, and inflammatory bowel diseases, andautoimmune disease(s). Also, disclosed are compositions comprising theheteroarylcompounds, as well as methods for their preparation.(see formula III)