A new and distinct cultivar of Hydrangea macrophylla plant named ‘Little Bo Peep’, characterized by its remontant (reblooming) trait, flowering on old wood and new growth of the season small, medium pink mophead inflorescences or medium blue inflorescences in non-aluminum or aluminum based media, respectively compact, mounded to spreading growth habit lustrous, dark green foliage reddish green stems and petioles and moderate resistance to powdery mildew and leaf spot.