A tissue anchor 10 including a body 12 having a first section 14 and a second section 16 displaceable relative to one another. Each section carries at least one protrusion 26 28, for example barbs or micro-needles, and at least one protrusion on at least one section is inclined towards a protrusion on the other section. The protrusions may extend in a direction that is substantially parallel to the direction of displacement. Each section may carry a plurality or different number of protrusions. The body sections may be displaced between a deployed (Fig. 2) and un-deployed state (Fig. 1) and their positions may be fixed using a lock 36. The anchor may have a coupling 38 provided on the body to receive a suture. The anchor may be made from bioabsorbable or porous material. An array of anchors may be used in a wound closure system. Two or more anchors may be deployed in parallel lines on either side of a wound using a template (60 Fig. 14). A suture (S Fig. 12) may be tethered between the anchors. The anchors may also be used for bio-sensing or drug delivery (Fig. 21a-d).