CALITOR SCIENCES, LLC;SUNSHINE LAKE PHARMA CO., LTD.
发明人:
XI, NING
申请号：
CA2898294
公开号：
CA2898294A1
申请日:
2014.02.15
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention provides hetero aromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially phosphatidylinositol 3-kinases (PI3 kinases) and mTOR, and in modulating inter- and/or intra-cellular signaling activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
