TAFESSE, LAYKEA,YAO, JIANGCHAO,YU, JIANMING,GOEHRING, R. RICHARD
申请号：
CA2948144
公开号：
CA2948144A1
申请日:
2015.05.05
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention provides compounds as represented by Formula I or I' and pharmaceutically acceptable salts, solvates, and diastereomers thereof: Wherein R1, R2, R2a, R3, and R4 are defined in the disclosure. The invention also provides compounds of Formulae II, III, and A-H, and pharmaceutically acceptable salts, solvates, and diastereomers thereof. In certain embodiments, Compounds of the Invention are useful for treating pain, constipation, and other conditions as delineated in the disclosure. Without wishing to be bound by any theory, it is believed that Compounds of the Invention are effective in treating conditions that are modulated by activity of opioid and/or ORL-1 receptors.
